TME Pharma

The publications contained in this archive section are provided for historical purposes only. The views expressed in the publications are those of their respective authors and do not reflect the views of TME Pharma. TME Pharma disavows any obligation to update or correct the information contained in these publications.

Jarosch, F., Buchner, K. & Klußmann, S.
In vitro selection using a dual RNA library that allows primerless selection.
Nucleic Acids Res. 2006, Vol. 34(12), e86.
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P. Kobelt, S. Helmling, A. Stengel, B. Wlotzka, V. Andresen, B. F. Klapp, B. Wiedenmann, S. Klussmann, and H. Mönnikes
Anti-ghrelin spiegelmer NOX-B11 inhibits neurostimulatory and orexigenic effects of peripheral ghrelin in rats.
Gut 2006, Vol. 55(6), 788-792
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Schlesinger, J, Bergmann, R., Klussmann, S. & Wuest, F.
Synthesis and radiopharmacological characterisation of 86Y- and 68Ga-labelled L-RNA oligonucleotides as molecular probes for positron emission tomography (PET).
Lett. Drug Des. Discov. 2006, Vol. 3(5), 330-335.
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Gnaccarini, C., Peter, S., Scheffer, U., Vonhoff, S., Klussmann, S. & Göbel, M. W.
Site specific cleavage of RNA by a metal free artificial nuclease attached to antisense oligonucleotides.
J. Am Chem. Soc. 2006, Vol. 128(24), 8063-8067.
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Rypniewsky, W., Vallazza, M., Perbandt, M., Klussmann, S., DeLucas, L. J., Betzel, C. & Erdmann, V. A.
The first crystal structure of an RNA racemate.
Acta Crystallogr. D Biol. Crystallogr. 2006, Vol. 62(Pt 6), 659-664.
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Purschke, W. G., Eulberg, D., Buchner, K., Vonhoff, S. & Klussmann, S.
An L-RNA-based aquaretic agent that inhibits vasopressin in vivo.
Proc. Natl. Acad. Sci. USA 2006, Vol. 103, 5173-5178.
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Helmling, S., Jarosch, F. & Klussmann, S.
The promise of ghrelin antagonism in obesity treatment.
Drug News Perspect. 2006, Vol. 19(1), 13-20.
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Eulberg, D., Jarosch, F., Vonhoff, S. & Klussmann, S.
Spiegelmers for Therapeutic Applications.
The Aptamer Handbook, Functional Oligonuleotides and Their Applications 2006, Ed. S. Klussmann, Wiley-VCH Weinheim.

Klussmann, S. (ed.)
The Aptamer Handbook. Functional Oligonucleotides and Their Applications.
Wiley-VCH Weinheim, 2006.

Denekas, T., Troeltzsch, M., Vater, A., Klussmann, S. & Messlinger, K.
Inhibition of stimulated meningeal blood flow by a calcitonin gene-related peptide binding mirror-image RNA oligonucleotide.
Brit. J Pharmcol. 2006, Vol. 148(4), 536-543.
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Shearman, L. P., Wang, S.-P., Helmling, S., Stribling, D. S., Mazur, P., Ge, L., Wang, L., Klussmann, S., Macintyre, D. D., Howard, A. D. & Strack, A. M.
Ghrelin neutralization by an RNA-Spiegelmer ameliorates obesity in diet-induced obese mice.
Endocrinology 2006, Vol. 147(3), 1517-1526.
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