Glioblastoma Treatment with Irradiation and Olaptesed Pegol (NOX-A12) in MGMT Unmethylated Patients (GLORIA)
Glioblastoma multiforme (GBM) is one of the deadliest and most aggressive forms of brain cancer. Patients with this devastating orphan disease are faced with extremely poor prognosis and a staggering 95% of them will not survive beyond 5 years. The standard of care – a combination treatment, including surgery, radiotherapy and chemotherapy – unfortunately is not curative. Moreover, not all patients are eligible or would benefit from chemotherapy, which further limits the efficacy of the treatment. There is a huge unmet need for an effective approach to treat GBM that prevents tumor recurrence. Our approach is built on research and data suggesting that tumor microenvironment (TME) plays a critical role in how effective anti-cancer therapies are at fighting the disease.
GLORIA is Phase 1/2 study in glioblastoma (brain cancer) patients resistant to standard chemotherapy (unmethylated MGMT promoter) consisting of a dose-escalation part with NOX-A12 plus radiotherapy and three additional arms combining NOX-A12 with radiotherapy plus bevacizumab or pembrolizumab, or NOX-A12 plus radiotherapy in patients with complete tumor resection.
Results generated and reported to date indicate:
Promising and exciting efficacy data in NOX-A12 monotherapy + radiotherapy, and in combination with bevacizumab
1. Giordano (2022) ASCO Annual Meeting Presentation #2050 link
2. TME Pharma Press Release 23 June 2022 link
RT = Radiotherapy; Beva = bevacizumab. Standard of care = RT + chemotherapy